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In-line filter system – a blood bag system for leukocyte filtration

For blood donation and component processing, Fresenius Kabi offers medical devices. These include cell separators (apheresis systems), autotransfusion devices, blood bag and filter systems as well as related blood processing equipment. Component processing consists of the separation and collection of certain blood cells.

Blood Cell Separator

The Fresenius cell separator has three areas of application:

  • Donate blood cells: obtaining cells from the blood of a donor for transfusion, for example for treating coagulation dysfunctions or leukemia patients
  • Remove cancer cells: removing diseased cells or blood plasma from the blood of a patient with leukemia or an autoimmune disease, i. e., in patients with disorders where the body produces defense substances against its own cells
  • Collect a patient’s cells: collecting cells from a patient's own blood for re-infusion, for example prior to operation.

A cell separator is primarily used to collect blood platelets or thrombocytes. While red blood cells mainly transport oxygen and other blood cells ward off pathogens, thrombocytes play an important role in blood clotting. Patients with too few thrombocytes suffer from an inability of the blood to coagulate properly. Injuries can lead to potentially dangerous bleeding. One example of the cause of thrombocyte deficiency is cancer therapy. Doctors infuse patients with healthy donor thrombocytes following treatment.

Thrombocytes are obtained most effectively with a blood cell separator. The machine, which works like a centrifuge, gently separates thrombocytes from the other blood components. Components that are not needed are immediately returned to the donor. Because only the thrombocytes are taken, which regenerate much quicker than red blood cells, a donor may donate much more frequently than in regular whole-blood donations. The cell separator also allows a much larger number of thrombocytes to be collected per donation than in whole blood. All patients who require a large number of thrombocytes can benefit double from the procedure – regular transfusions include thrombocytes from several sources but a blood cell separator can reduce the number of donors needed per transfusion. This allows a doctor to select thrombocytes from the most appropriate donors. This is important because the efficacy of the thrombocytes improves when the blood groups of donors and recipients match.

A cell separator can separate thrombocytes from other blood cells; it can also support the treatment of leukemia patients by removing diseased cells directly from the blood. Since leukemic cancer cells quickly reproduce, this procedure cannot heal a patient. But it relieves the strain on the kidneys by considerably lowering the number of destroyed cancer cells that must be removed from the blood following treatment.

Although rarely used, another application of the blood cell separator is quickly gaining in importance. Doctors can use the device to remove stem cells from the blood of a cancer patient. Through pre-treatment bone marrow stem cells start to reproduce and partially move into the blood stream. These stem cells can be collected almost like platelets. This way surgery to obtain stem cells directly from bone marrow can be avoided.

The treatment subsequently used to combat cancer cells damage the stem cells from which all other blood cells are made. If the patient receives healthy stem cells after chemotherapy, healthy blood cells can develop quicker, for example the platelets that are important for hemostasis and coagulation.

Blood bag systems

Blood bag systems are the foundation for worldwide blood supply by "classical" blood donation. More than 90 percent of all blood donations are processed in these systems that consist of up to six different bags with variable functions.

A combination of bags with venous cannulae and integrated needle protection, pre-donation sampling pouches and different filtration devices form the basis for highly professional whole blood collection systems. They allow producing different blood component preparations according to national and international standards. Blood donation and processing with these systems is supplemented by other devices such as automated scales and blood separators, sterile docking systems and sealers to name a few.

Contact

Fresenius Kabi AG
Else-Kröner-Str. 1
61352 Bad Homburg
Germany
T: +49 6172 686-0

www.fresenius-kabi.com
The HPC qualifies participants to handle health issues with confidence.

Comprehensive patient care begins with prevention. Fresenius Helios' occupational healthcare centers offer a wide range of workplace prevention services. In addition, the Helios Prevention Center (HPC) of Fresenius Helios offers programs for individual prevention and company health management in the form of checkups and health coaching at numerous locations around Germany.
 

Occupational Healthcare

The aim of effective occupational healthcare is to maintain and promote health, prevent harmful influences resulting from working life, detect illnesses and damage to health at an early stage, as well as reintegrate employees into the workplace after a longer period of absence due to illness.

In Germany, Helios offers fully comprehensive occupational medical care with a fixed, permanent contact person at 17 occupational healthcare centers. This covers everything from legally required examinations, health protection and promotion to risk assessments and recommendations for optimal workplace design.

Spain's leading occupational risk prevention companies Fraterprevención, MC Prevención, Premap and Unipresalud complement the Quirónsalud network, with more than 150 centers throughout Spain and a presence in Latin America and the Middle East.

 

Helios Prevention Center (HPC)

A check-up at the Helios Prevention Center provides an accurate picture of one's own state of health. Our participants at one of our six locations benefit from short waiting times, short distances and holistic lifestyle advice.

The HPC qualifies participants to handle health issues with confidence and enables them to achieve a performance grade that can function as a model. Health conscious and competent leadership can act as a beacon to bind together and motivate employees. HPC views itself as a partner to companies that want to actively promote the health of their employees. From a one-day checkup at a Helios clinic to health workshops lasting several days at beautifully situated resorts – our modular program combines Helios quality with the ambience of exclusive hotels. Studies show occupational healthcare measures generate outstanding cost-benefit ratios.

Contact

Helios Prevention Center
Service-Hotline: 0800-633 49 46
info@helios-preventioncenter.de

www.helios-preventioncenter.de

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Fresenius Helios
Fresenius Helios is one of the largest and most medically-advanced operators of both in- and outpatient care in Europe.

Fresenius Helios is the leading private healthcare provider in Europe serving with around 140 clinics and numerous outpatient facilities about 27 million people annually. Together with Fresenius Kabi, a provider of healthcare products for the critically and chronically ill, Fresenius Helios is part of the Fresenius healthcare group. With its 130,000 employees of the Helios Group in Germany and Quirónsalud in Spain and Latin America, Fresenius Helios generated total sales of more than 13.5 billion euros in 2025.

Helios Germany operates more than 80 hospitals, about 200 outpatient care centers with, six prevention centers and 30 occupational medicine centers. Helios treats approximately 5.6 million patients annually, of whom 4 million are outpatients. Since its beginnings, Helios has focused on measurable, high medical quality as well as data transparency and is better than the German average in more than 90 percent of the quality targets. With about 80,000 employees, Helios generated sales of €8.1 billion in 2025. With its own 35 training centers, Helios represents education and training in the healthcare sector. Helios Germany is headquartered in Berlin.

Quirónsalud has 57 hospitals, including seven in Latin America, around 130 outpatient centers and more than 300 occupational risk prevention centers, and treats approximately 22 million patients annually, of whom 20 million are outpatients. Quirónsalud has about 50,000 employees and generated sales of more than €5.4 billion in 2025. 

 

Contact

Helios Kliniken GmbH
Friedrichstr. 136
10117 Berlin
Germany
T +49 30 521 321-0

www.helios-gesundheit.de

Contact

Grupo Hospitalario Quirónsalud
C\ Zurbarán 28
28010 Madrid
Spain

www.quironsalud.es/

Fresenius is one of the top 40 companies in Germany in terms of market capitalization and is included in Germany's leading index, the DAX. We are also listed in the STOXX Europe 600 Health Care, the FTSEurofirst 300 and the DAXsector Pharma & Healthcare indices.

Fresenius ordinary shares are traded on the stock exchanges in Frankfurt, Düsseldorf and Munich.

At the end of July 2022, Fresenius SE & Co. KGaA's capital stock was 563,237,277 ordinary shares. The shares are notional no-par-value shares. Each share represents €1.00 of the capital stock.

 

Basic Share information

Ordinary share

Securities identification no.

578 560

Ticker symbol

FRE

ISIN

DE0005785604

Bloomberg symbol

FRE GR

Reuters symbol

FREG.de

Main trading location

Frankfurt/Xetra

Paying agent

Deutsche Bank AG, Taunusanlage 12, 60325 Frankfurt am Main, Germany

Key data

2024 2023 2022

Numbers of shares

563,237,277  563,237,277  563,237,277

Stock exchange quotation1 in € 

High

 34.85  31.11  37.88

Low

 24.54  23.46  20.04

Year-end quotation

 33.54  28.07  26.25

Market capitalization2 in million €

 18,891  15,810  14,785

Total dividend distribution in million €

 5633  -  518

Dividend per share in €

1.003 -  0.92

Earnings per share in €4 

 3.11  2.67  3.08

    • 1 Xetra closing price on the Frankfurt Stock Exchange
    • 2 Total number of ordinary shares multiplied by the respective Xetra year-end quotation on the Frankfurt Stock Exchange
    • 3 Proposal
    • 4 Net income attributable to shareholders of Fresenius SE & Co. KGaA; before special items

Contact

Florian Feick

Vice President Investor Relations
Deputy Head of Investor Relations
T: +49 (0) 6172 608-5167
florian.feick@fresenius.com

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Event

February 25, 2026 - 01:30 pm | Bad Homburg, Germany

Conference Call Full Year Results 2025
Webcast replay Q4/25 Aide Memoire Presentation Investor News Transcript Import (ICS)

Nutrition is a topic which is all around us, day by day. While we often talk about obesity and weight loss diets we actually overlook that the opposite, meaning mal- or undernutrition, can be as detrimental. We talk about malnutrition when our body is not provided with sufficient energy and nutrients over several days. These nutrients, for example protein, carbohydrates, fats, vitamins and minerals, are necessary to ensure all essential functions of the body.

When our nutritional status is not optimal our body will get w​eaker in its reaction towards challenges, such as a disease, a cold or an infection. Improving our nutritional status will therefore support and protect our body.

Enteral Nutrition

Every normal form of nutrition is actually enteral. The word, which comes from the Greek “enteron,” or intestines, means, “using the gastrointestinal tract.” Enteral nutrition therapies are designed for patients who cannot nourish themselves sufficiently but still have an adequate digestive function. It is therefore ideal for patients who experience problems chewing or swallowing, loss of appetite, suffer from neurological or gastro-intestinal diseases, or are unconscious. Enteral nutrition is administered via sip feeds or also tube feeds.

If you are not able to eat enough, sip feed nutrition can help to make up for this deficit. Sip feed nutrition can be taken by mouth, swallowed and digested like normal food. It is flavorful, liquid food and contains all nutrients such as carbohydrates, fats and fiber as well as vitamins, minerals and trace elements.
Sip feed nutrition is balanced. It contains all the nutrients required by a person. Therefore, it can be drunk or eaten in addition to normal food but is also suitable as a sole source of nutrition.

Tube feed nutrition can help you to meet your nutritional needs in times when you are not able to eat enough.
Tube feeding is a procedure used for administering liquid nutrition directly into the stomach or small intestine. To do this, a thin tube (probe) is inserted either through the nose (nasal probe) or through the abdomen into the stomach.

Parenteral Nutrition

Patients who are given Fresenius Kabi infusion solutions receive all the components of balanced nutrition: carbohydrates, amino acids and fats as well as minerals, vitamins and trace elements. The composition of these nutritional solutions can be precisely balanced to feed a patient for any period of time.

Parenteral nutrition is necessary when the stomach or intestine – for instance due to an illness or operation – can no longer perform their tasks. A doctor may also decide that a patient should receive parenteral nutrition prior to an operation or during lengthy examinations when he or she is not allowed to eat. In intravenous nutrition, all key nutrients enter the bloodstream as molecular components. A patient can rely on parenterally given nutrients for a long period of time.

There are a number of liquids with a variety of compositions that can be used for parenteral nutrition therapy either on their own or as a mixture. When deciding on the best nutritional therapy, the general condition of the patient plays an important role, as well as a patient’s age and weight. There are also solutions for patients with kidney or liver disease that contain a special composition of amino acids. Fresenius Kabi offers amino acids and carbohydrates as single components but also as a combination that contains both nutritional elements. Three-chamber bags contain all three important nutrients including fats.

Carbohydrates are the most important source of energy

Carbohydrates are the most important source of energy in parenteral nutrition. Often, glucose alone is sufficient. Glucose is a "universal fuel" that can be utilized by all the body’s cells, making it a standard nutrient for parenteral nutrition. Doctors can choose between solutions with different glucose concentrations. Combined solutions also contain other nutritional components besides carbohydrates.

Amino acids are essential for parenteral nutrition

Amino acids are the smallest components of proteins that perform many tasks in the body. Every organ requires proteins for its structure and function. Proteins transport, act as messengers, fight germs or control and create vital metabolic reactions. They are also important building blocks for muscles, hair and finger nails, for example.

All proteins consist of different amino acids. Therefore, amino acids are also indispensable for parenteral nutrition. Fresenius Kabi offers solutions containing amino acids in an ideal composition that the body can use to generate the required proteins.

Fats contain lots of energy and essential fatty acids

Fats contain not only a lot of energy, but also important fatty acids that the body itself cannot produce. These essential fatty acids help build up cell membranes and transmitters that regulate the metabolism.

Patients who are fed parenterally receive the fats as microscopic droplets that are suspended in a liquid known as emulsion. When this emulsion is infused into the blood stream, the tiny droplets disperse in the blood and can be absorbed by the body's cells. Fat emulsions help doctors to provide critically-ill patients with quickly-available energy while offering a reliable source of essential fatty acids.

Contact

Fresenius Kabi AG
Else-Kröner-Str. 1
61352 Bad Homburg
Germany
T: +49 6172 686-0

www.fresenius-kabi.com

Video

Explanatory video: Nutrition therapy

  • What happens when the normal intake of food is no longer possible?

Industrial production of infusion solutions at Fresenius Kabi's plant in Friedberg.

Fresenius Kabi is a global healthcare company that specializes in lifesaving medicines and technologies for infusion, transfusion and clinical nutrition. The company’s products and services are used for the therapy and care of critically and chronically ill patients. 

Its product portfolio comprises a range of highly complex biopharmaceuticals, clinical nutrition, medical technologies, and I.V. generic drugs. Within biopharmaceuticals, Fresenius Kabi offers, among others, biosimilar drugs with a focus on autoimmune diseases and oncology. The company’s clinical nutrition portfolio includes a wide selection of enteral and parenteral nutrition products. In the segment of medical technologies, Fresenius Kabi offers vital disposables, infusions pumps, apheresis machines, cell therapy devices, and more. 

Fresenius Kabi employs over 40,000 people worldwide. In 2025 the company reported sales of more than €8.5 billion. Fresenius Kabi AG is a wholly owned subsidiary of the Fresenius SE & Co. KGaA healthcare group and one of the two Operating Companies of Fresenius.

Contact

Fresenius Kabi AG
Else-Kröner-Str. 1
61352 Bad Homburg
Germany
T: +49 6172 686-0

Fresenius Kabi

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Fresenius Career

Fresenius Kabi has agreed to collaborate with Phlow Corporation, a public benefit company, to expand access to affordable sterile injectables formulated for U.S. children’s hospitals and to help strengthen the supply chain for U.S.-sourced API and essential medicines. The companies will work together to supply private-labelled products, co-develop and manufacture novel products and make essential medicines rapidly available in the event of a public health emergency.

Fresenius Kabi has agreed to collaborate with Phlow Corporation, a public benefit company, to expand access to affordable sterile injectables formulated for U.S. children’s hospitals and to help strengthen the supply chain for U.S.-sourced API and essential medicines. The companies will work together to supply private-labelled products, co-develop and manufacture novel products and make essential medicines rapidly available in the event of a public health emergency.

Ensure financial flexibility, maintain our investment grade rating, limit refinancing risks and optimize the cost of capital are the main objectives in Fresenius’s financing strategy.

To remain financially flexible, we maintain adequate liquidity headroom. We are committed to our investment grade rating, which provides us with advantages with respect to market access and funding costs.

Our refinancing risks are limited due to a balanced maturity profile that is characterized by a broad range of maturities with a high proportion of mid- and long-term debt up to 2034. Relevant financing instruments include bonds, Schuldschein Loans and bank loans. In addition, Fresenius maintains a commercial paper program. 

Another key objective of Fresenius’ financing strategy is to optimize the cost of capital by employing an adequate mix of equity and debt.

In 2025, deleveraging will remain a key priority. Fresenius has upgraded its leverage target corridor to 2.5 to 3.0x net debt/EBITDA (previously 3.5 to 3.0x). This allows us to stay financially flexible while solidifying our solid investment grade rating.
 

Fresenius Group

1 Prior-year figures have been adjusted due to the deconsolidation of Fresenius Medical Care operations

2 Before special items

3 At average exchange rates for both net debt and EBITDA; pro forma closed acquisitions/divestitures, including lease liabilities, including Fresenius Medical Care dividend; Net debt adjusted for the valuation effect of the exchangeable bond

Contact

Elisabeth Truckenbrodt

Director Investor Relations
T: +49 (0) 6172 608-2486
elisabeth.truckenbrodt@fresenius.com

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